26 sCD14 in macrophages from patients with cystic fibrosis: Origin and involvement in inflammatory functions

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Impaired Functions of Macrophage from Cystic Fibrosis Patients: CD11b, TLR-5 Decrease and sCD14, Inflammatory Cytokines Increase

BACKGROUND Early in life, cystic fibrosis (CF) patients are infected with microorganisms. The role of macrophages has largely been underestimated in literature, whereas the focus being mostly on neutrophils and epithelial cells. Macrophages may however play a significant role in the initiating stages of this disease, via an inability to act as a suppressor cell. Yet macrophage dysfunction may b...

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ژورنال

عنوان ژورنال: Journal of Cystic Fibrosis

سال: 2015

ISSN: 1569-1993

DOI: 10.1016/s1569-1993(15)30203-4